TERC FISH (oral, anal, and cervical)
Gains of the long arm of chromosome 3 (TERC) have been observed in intraepithelial cells from both the cervix and anus in patients with high grade HPV viral infections. Acupath Acuprobe™ TERC FISH provides reliable results to determine TERC gene amplification in liquid based cytology specimens. The detection of TERC amplification in these patients can be an initial indicator that dysplasia may occur in these cells.
Acupath Laboratories utilizes the FDA cleared FISH probes from Abbott Molecular to detect HER2/neu amplification (PathVysion®). Utilized in combination with IHC staining and biopsy review, the PathVysion kit provides information on companion diagnostic responsiveness and used to predict disease-free and overall survival in stage II, node-positive breast cancer patients. Results of the FISH testing for HER2/neu amplification should not be the only factor when considering treatment of patients with stage II, node-positive breast cancer.
Melanoma FISH | Spitz Nevus FISH
The Acupath Laboratories Acuprobe ™ Melanoma FISH panel is a combination of four individual probes that can help distinguish skin biopsies that are melanocytic lesions verses a benign nevus. Many specimens are difficult to assess with routine biopsy and IHC methodologies, and the additional genetic information gained from FISH allows for the detection of genetic changes that may be indicative of melanoma.
The Acuprobe ™ Spitz Nevus panel consists of a probe for HRAS and CCND1. Amplification of HRAS is associated with Spitz Nevus.